点击化学利用四嗪(Tetrazine)碳纳米管实现预靶向肿瘤成像

西安瑞禧生物一家以客户为中心的生物技术公司。我们致力于生产和供应高纯度聚乙二醇连接物，点击化学工具和先进的生物标记试剂，如染料标记和生物素标记化合物，我们的客户遍布世界各地。

利用TCO和Tz之间快速的正交切割反应，把Tz搭载于肿瘤靶向性的纳米材料单壁碳纳米管SWCNTs上（Tz@SWCNTs），实现对肿瘤的预靶向激活。其主要原理：利用通透性增强与滞留效应，使Tz@SWCNTs在肿瘤组织中积累。通过TCO前药分子或探针，由在肿瘤处富集的Tz进行正交切割。

通过研究tAMC与Tz@SWCNTs之间的释放动力学，相比于mTZ小分子，Tz@SWCNTs对tAMC的衰减反应性更强，且能在生理环境下，对MCF-7癌细胞进行靶向并激活tAMC荧光。

将阳离子染料半菁HCA和TCO相连得到近红外荧光探针tHCA用于通过生物正交释放反应的激活近红外荧光探针。该探针在生理环境下因Tz@SWCNTs的激发快速释放，并在720nm下发出强荧光。

瑞禧相关产品：

Tetrazine-NHS Ester

Methyltetrazine-NHS Este

Tetrazine-Sulfo-NHS Ester

Methyltetrazine-Sulfo-NHS Ester

Tetrazine-PEG5-NHS Ester

Methyltetrazine-PEG4-NHS Ester

Methyltetrazine-PEG5-NHS Ester

Methyltetrazine-PEG4-Sulfo-NHS Ester

Methyltetrazine-Acid

Tetrazine-Acid

Methyltetrazine-PEG4-Acid

PC Methyltetrazine-NHS Ester

R-CT-013 Methyltetrazine-Amine

Tetrazine-Amine

Methyltetrazine-Propylamine

Methyltetrazine-PEG4-Amine

Methyltetrazine-PEG4-Maleimide

Bis-sulfone-PEG4-Tetrazine

ThioLinker-Tetrazine

Methyltetrazine-DBCO

Methyltetrazine-PEG12-DBCO

Methyltetrazine-PEG4-Alkyne

Methyltetrazine-PEG4-Azide

Methyltetrazine-mPEG,5 kDa

Methyltetrazine-mPEG, 10 kDa

Methyltetrazine-mPEG, 20 kDa

Methyltetrazine-mPEG, 30 kDa

Biotin-PEG4-Methyltetrazine

Cy3 Tetrazine

Cy3 Methyltetrazine

TAMRA Tetrazine

TAMRA Methyltetrazine

Cy7 Methyltetrazine

MethylTetrazine-amine HCl salt

Methyltetrazine-PEG4-COOH

MPEG-Tetrazine 

MethylTetrazine-amine HCl salt

Methyltetrazine-propylamine HCl salt

Methyltetrazine-PEG4-Alkyne  

Tetrazine-PEG4-amine HCl salt

Me-Tetrazine-PEG4-amine HCl salt

Tetrazine-PEG5-COOH

Tetrazine-PEG5-NHS ester