- 029-86354885
- 13309186942
点击化学利用四嗪(Tetrazine)碳纳米管实现预靶向肿瘤成像
西安瑞禧生物一家以客户为中心的生物技术公司。我们致力于生产和供应高纯度聚乙二醇连接物,点击化学工具和先进的生物标记试剂,如染料标记和生物素标记化合物,我们的客户遍布世界各地。
利用TCO和Tz之间快速的正交切割反应,把Tz搭载于肿瘤靶向性的纳米材料单壁碳纳米管SWCNTs上(Tz@SWCNTs),实现对肿瘤的预靶向激活。其主要原理:利用通透性增强与滞留效应,使Tz@SWCNTs在肿瘤组织中积累。通过TCO前药分子或探针,由在肿瘤处富集的Tz进行正交切割。
通过研究tAMC与Tz@SWCNTs之间的释放动力学,相比于mTZ小分子,Tz@SWCNTs对tAMC的衰减反应性更强,且能在生理环境下,对MCF-7癌细胞进行靶向并激活tAMC荧光。
将阳离子染料半菁HCA和TCO相连得到近红外荧光探针tHCA用于通过生物正交释放反应的激活近红外荧光探针。该探针在生理环境下因Tz@SWCNTs的激发快速释放,并在720nm下发出强荧光。
瑞禧相关产品:
Tetrazine-NHS Ester
Methyltetrazine-NHS Este
Tetrazine-Sulfo-NHS Ester
Methyltetrazine-Sulfo-NHS Ester
Tetrazine-PEG5-NHS Ester
Methyltetrazine-PEG4-NHS Ester
Methyltetrazine-PEG5-NHS Ester
Methyltetrazine-PEG4-Sulfo-NHS Ester
Methyltetrazine-Acid
Tetrazine-Acid
Methyltetrazine-PEG4-Acid
PC Methyltetrazine-NHS Ester
R-CT-013 Methyltetrazine-Amine
Tetrazine-Amine
Methyltetrazine-Propylamine
Methyltetrazine-PEG4-Amine
Methyltetrazine-PEG4-Maleimide
Bis-sulfone-PEG4-Tetrazine
ThioLinker-Tetrazine
Methyltetrazine-DBCO
Methyltetrazine-PEG12-DBCO
Methyltetrazine-PEG4-Alkyne
Methyltetrazine-PEG4-Azide
Methyltetrazine-mPEG,5 kDa
Methyltetrazine-mPEG, 10 kDa
Methyltetrazine-mPEG, 20 kDa
Methyltetrazine-mPEG, 30 kDa
Biotin-PEG4-Methyltetrazine
Cy3 Tetrazine
Cy3 Methyltetrazine
TAMRA Tetrazine
TAMRA Methyltetrazine
Cy7 Methyltetrazine
MethylTetrazine-amine HCl salt
Methyltetrazine-PEG4-COOH
MPEG-Tetrazine
MethylTetrazine-amine HCl salt
Methyltetrazine-propylamine HCl salt
Methyltetrazine-PEG4-Alkyne
Tetrazine-PEG4-amine HCl salt
Me-Tetrazine-PEG4-amine HCl salt
Tetrazine-PEG5-COOH
Tetrazine-PEG5-NHS ester
序号 | 新闻标题 | 浏览次数 | 作者 | 发布时间 |
---|---|---|---|---|
1 | 瑞禧定制石墨烯/聚己内酯、辛伐他汀/聚己内酯、聚乳酸-乙醇酸/氧化锌等材料合成静电纺丝纤维膜 | 7 | 瑞禧生物 | 2021-04-16 |
2 | 吲哚菁绿ICG与Mal/Azide/DBCO/Tz/Alkyne等活性基团及磷脂DSPE形成近红外荧光纳米探针 | 8 | 瑞禧生物 | 2021-04-16 |
3 | 瑞禧吲哚菁绿ICG定制-荧光ICG标记多糖的方法步骤解析 | 7 | 瑞禧生物 | 2021-04-15 |
4 | 瑞禧合成氯氧化锆-聚乙烯醇、聚对苯二甲酰对苯二胺液晶体等纳米纤维静电纺丝 | 8 | 瑞禧生物 | 2021-04-15 |
5 | 瑞禧定制聚酯、聚酰胺、聚乙烯醇、聚丙烯腈柔性和聚氨酯弹性体高聚物静电纺丝 | 20 | 瑞禧生物 | 2021-04-15 |
6 | 超分子金纳米棒介导近红外二区光热基因组增强肿瘤免疫治疗 | 13 | 瑞禧生物 | 2021-04-13 |
7 | 瑞禧定制CaO-P2O5-SiO2系统溶胶/Al2O3块状石英纤维气凝胶 | 15 | 瑞禧生物 | 2021-04-13 |