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PCL2K-PEG2K免费试用活动及产品介绍

时间:2016-10-12 17:16:26       浏览:5222
<p style="text-align:center;"><span style="font-size:14.0pt;">嵌段共聚物产品免费试用活动及产品介绍</span></p><p style="text-align:center;"><strong><span style="font-size:20.0pt;">&nbsp;</span></strong></p><p><span style="">【活动内容】:</span></p><p><span style="">为答谢广大客户对西安瑞禧生物科技有限公司的常年支持,我公司特举办嵌段共聚物产品免费试用活动,目前参与活动的产品有</span>1<span style="">种,后期我们会不断增加活动产品的数量。</span></p><p><span style="">【活动时间】:</span></p><p>2016<span style="">年</span>10<span style="">月</span>12<span style="">号</span>-<span style="">长期</span></p><p><span style="">【活动参与条件】:</span></p><p><span style="">添加瑞禧生物官方微信号,在朋友圈转发此条信息并需三位好友再次转发此条信息,截图发至瑞禧生物官方微信号上即可免费领取。</span></p><p style="text-align:center;"><img src="/upload/month_1610/201610121740278646.png" alt="" /><br /></p><p><span style="">【参与产品的列表】:</span></p><p><span style="font-size:12.0pt;">1.</span> mPEG-PCL</p><p><span style="">产品信息:</span></p><p><span style="">Name</span><span style="">:</span><span style=""> PEG2000-PCL2000</span></p><p><span style="">Molecular Weight</span><span style="">:</span><span style=""> PEGMW:2000&nbsp; PCL MW: 2000</span></p><p><span style="">Cat.#</span><span style="">:</span><span style=""> R-V3518</span></p><p><span style="">Lot.#</span><span style="">:</span><span style=""> RP0160881</span></p><p><span style="">Stability</span><span style="">:</span><span style=""> 12 months</span></p><p><span style="">Storage</span><span style="">:</span><span style=""> -20°C in thedark</span></p><p><span style="">结构式:</span></p><p><br /></p><p><span style="">&nbsp;</span></p><p><span style="">&nbsp;<img src="/upload/month_1610/201610121747293575.png" alt="" /></span></p><p><span style="">&nbsp;</span></p><p><span style="">&nbsp;</span></p><p><span style="">核磁图谱:</span></p><p><img src="/upload/month_1610/201610121747409325.png" alt="" /><br /></p><p><span style="font-size:12.0pt;">&nbsp;</span></p><p><span style="font-size:12.0pt;">GPC</span><span style="font-size:12.0pt;">图谱</span></p><p><img src="/upload/month_1610/201610121747502208.png" alt="" /><br /></p><p><img src="/upload/month_1610/201610121748006923.png" alt="" /><br /></p><p><span style="">&nbsp;</span></p><p>2. <span style="">后续会陆续添加更多新产品作为试用,请持续关注我公司官方网站</span>www.xarxbio.com</p><p><span style="">【活动解释】:</span></p><p>1.<span style="">试用产品包含邮费和包装费,不收取任何费用,没有其他任何附加条件;</span></p><p>2.<span style="">试用产品的产品均为质量确保的商品,无任何瑕疵或质量问题;</span></p><p>3.<span style="">试用产品,一个人只能申请一次,包装量为</span>50mg<span style="">;</span></p><p>4.<span style="">此活动最终解释权归西安瑞禧生物科技有限公司。</span></p><p><strong><span style="">瑞禧生物科技有限公司可以提供的嵌段共聚物系列产品:</span></strong></p><p><span style="">PCL-PEG-MAL,&nbsp;PCL-PEG-NHS, &nbsp;PCL-PEG-NH2, &nbsp;PCL-PEG-COOH, &nbsp;PCL-PEG-Folate</span></p><p><span style="">PLGA-PEG-MAL,PLGA-PEG-NHS,PLGA-PEG-NH2,PLGA-PEG-COOH,&nbsp;PLGA-PEG-Folate</span></p><p><span style="">PLA-PEG-MAL,&nbsp;PLA-PEG-NHS, &nbsp;PLA-PEG-NH2, &nbsp;PLA-PEG-COOH, &nbsp;PLA-PEG-Folate</span></p><p><span style="">&nbsp;</span></p><p><span style="">mPEG-PLGA-NHS</span></p><p><span style="">mPEG-PLGA-Mal</span></p><p><span style="">mPEG-PLGA-COOH</span></p><p><span style="">mPEG-PLGA-NH2</span></p><p><span style="">mPEG-PLGA-OH</span></p><p><span style="">&nbsp;</span></p><p><span style="">mPEG-SS-PLGA-COOH</span></p><p><span style="">mPEG-SS-PLGA-NHS</span></p><p><span style="">mPEG-SS-PLGA-MAL</span></p><p><span style="">mPEG-SS-PLGA-NH2</span></p><p><span style="">mPEG-SS-PLGA-OH</span></p><p><span style="">&nbsp;</span></p><p><span style="">PLGA-SS-mPEG</span></p><p><span style="">PLGA-SS-PEG-PLGA</span></p><p><span style="">PLGA-SS-PEG-MAL</span></p><p><span style="">PLGA-SS-PEG-COOH</span></p><p><span style="">PLGA-SS-PEG-NH2</span></p><p><span style="">PLGA-SS-PEG-NHS</span></p><p><span style="">&nbsp;</span></p><p><span style="">PAMAM-PLGA-COOH&nbsp;&nbsp; &nbsp;&nbsp; PAMAMG2 16 arm&nbsp; or&nbsp; PAMAM G3&nbsp;32 arm</span></p><p><span style="">PAMAM-PGA-NHS&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp; PAMAMG2 16 arm&nbsp; or&nbsp; PAMAM G3&nbsp;32 arm</span></p><p><span style="">PAMAM-PLGA-MAL&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp; PAMAMG2 16 arm&nbsp; or&nbsp; PAMAM G3&nbsp;32 arm</span></p><p><span style="">PAMAM-PLGA-NH2&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PAMAMG2 16 arm&nbsp; or&nbsp; PAMAM G3&nbsp;32 arm</span></p><p><span style="">&nbsp;</span></p><p><span style="">PLGA-Poly(L-lysine)&nbsp;&nbsp;&nbsp; PLGA-b-PLL&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></p><p><span style="">PLGA-Poly(L-Glutamicacid) PLGA-b-PLG&nbsp; PLGA-b-PGUA&nbsp; </span></p><p><span style="">PLA-Poly(L-lysine)&nbsp;&nbsp;&nbsp; PLA-b-PLL&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></p><p><span style="">PLA-Poly(L-Glutamicacid) &nbsp;PLA-b-PLG&nbsp; </span></p><p><span style="">PCL-Poly(L-lysine)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; PCL-b-PLL &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></p><p><span style="">PCL-Poly(L-Glutamicacid) &nbsp;PCL-b-PLG</span>&nbsp;&nbsp; </p><p><span style="font-size:10.5pt;">mPEG-PLGA-PLL&nbsp; mPEG-PLGA-Poly(L-lysine)</span></p><p>&nbsp;</p><p><strong><span style="">瑞禧生物的其他两亲嵌段共聚物产品:</span></strong></p><p>PS-b-PAA<span style="">,</span>PS-b-PMMA<span style="">,</span>PS-b-PEG<span style="">,</span>PDLLA-b-PAA<span style="">,</span>PS-b-PDLLA<span style="">,</span>mPEG-PEI<span style="">,</span>PCL-b-PEI</p><p>PS-PPBD<span style="">,</span>mPEG-PLCL<span style="">,</span>PLCL-PEG-MAL<span style="">,</span>PLCL-PEG-NHS<span style="">,</span>PAA-b-PAMD<span style="">,</span>PAA-PMMA</p><p>PAA-PIPA<span style="">,</span>PnBuA-b-PAA<span style="">,</span>PMMA-b-PMAA<span style="">,</span>PtBMA-b-PEO<span style="">,</span>PMMA-b-PAA<span style="">,</span>PNPMA-b-PMAA</p><p>PEO-b-PAA<span style="">,</span>PEO-b-PAMD<span style="">,</span>PEO-b-PTMEG<span style="">,</span>PEO-PMAA<span style="">,</span>PIB-b-PAA<span style="">,</span>PIB-b-PMAA<span style="">,</span>PS-b-PAA</p><p>PS-b-PEO<span style="">,</span>PS-b-PMAA<span style="">,</span>PS-b-PPAA<span style="">,</span>PDMS-b-PAA<span style="">,</span>PDMS-b-PMAA<span style="">,</span>P2VP-b-PEO</p><p>P2VP-b-PMAA<span style="">,</span>PMMA-b-PNA<span style="">,</span>PMMA-b-PHEMA<span style="">,</span>PtBuA-b-P4VP<span style="">,</span>PMAA-b-PCL</p><p>PBd-b-PtBuA<span style="">,</span>PBd-b-PMMA<span style="">,</span>PBd-b-PCL<span style="">,</span>PBd-b-PLLA<span style="">,</span>PBd-b-PDLLA<span style="">,</span>PBd-b-P4VP</p><p>PIB-b-PtBuMA<span style="">,</span>PS-b-PANa<span style="">,</span>PIB-b-PMMA<span style="">,</span>PIB-b-PCL<span style="">,</span>PIB-b-P4VP<span style="">,</span>PS-b-PBPA</p><p>PS-b-PBd<span style="">,</span>PS-b-PEMA<span style="">,</span>PS-b-PLA<span style="">,</span>PS-b-PnBuMA<span style="">,</span>PS-b-PnBuMA<span style="">,</span>PMMA-PS-PMMA</p><p>PS-PAA-PS<span style="">,</span>PS-PCL-PS<span style="">,</span>P2VP-PS-P2VP<span style="">,</span>P2VP-PBd-P2VP<span style="">,</span>PS-PMMA-PS<span style="">,</span>PS-PBd-PMMA</p><p>PS-P2VP-PEO<span style="">,</span>P4VP-PCL-SH<span style="">,</span>PS-PCL-SH<span style="">,</span>PS-PEO-MAL<span style="">,</span>PMAA-PCL-SH</p><p>&nbsp;</p><p><strong><span style="">【</span>PEG-PCL<span style="">材料的介绍】:</span></strong></p><p><span style="">聚乙二醇</span>-b-<span style="">聚己内酯</span>, <span style="">作为两亲性高分子材料,可以做成胶束</span><span style="">并成为药物控释载体材料。生物可降解嵌段共聚物是有发展潜力的新型药物载体材料,可通过调节嵌段组成比例或加入符合要求的新嵌段来调控其物理、化学性质,具有良好的生物相容性,它正越来越多地被用作多种药物释放体系载体,包括非生物活性药物和生物活性药物,如蛋白质、多肽、抗原等。</span></p><p>&nbsp;</p><p><span style="">【<strong>具体产品展示</strong>】:</span></p><p>&nbsp;</p><p><span style="">产品展示一:</span></p><p><span style="">Name</span><span style="">:</span><span style=""> PCL5000-PEG5000-Rhodamine B</span></p><p><span style="">Molecular Weight</span><span style="">:</span><span style=""> PEG MW:5000&nbsp; &nbsp;PCLMW:5000</span></p><p><span style="">Cat.#</span><span style="">:</span><span style=""> R-1121-55K</span></p><p><span style="">Lot.#</span><span style="">:</span><span style=""> RP0161182</span></p><p><span style="">Stability</span><span style="">:</span><span style=""> 12 months</span></p><p><span style="">Storage</span><span style="">:</span><span style=""> -20°C in the dark</span></p><p style="text-align:center;"><strong><span style="font-size:12.0pt;">Structure</span></strong></p><p style="text-align:center;"><strong><span style="font-size:12.0pt;">&nbsp;</span></strong></p><p style="text-align: center;"><img src="/upload/month_1610/201610121748137288.png" alt="" /><br /></p><p><span style="font-size:12.0pt;">&nbsp;</span></p><table border="1" cellspacing="0" cellpadding="0"> <tbody><tr><td style="width:102.25pt;"><p style="text-align:center;"><span style="">Items</span></p></td><td style="width:155.15pt;"><p style="text-align:center;"><span style="">Specification</span></p></td><td style="width:168.7pt;"><p style="text-align:center;"><span style="">Results</span></p></td></tr><tr><td style="width:102.25pt;"><p style="text-align:center;"><span style="">Appearance</span></p></td><td style="width:155.15pt;"><p style="text-align:center;"><span style="">Pink solid</span></p></td><td style="width:168.7pt;"><p style="text-align:center;"><span style="">Pink solid</span></p></td></tr><tr><td style="width:102.25pt;"><p style="text-align:center;"><sup><span style="">1</span></sup><span style="">H NMR</span></p></td><td style="width:155.15pt;"><p style="text-align:center;"><span style="">Identical to the structure</span></p></td><td style="width:168.7pt;"><p style="text-align:center;"><span style="">Identical to the structure</span></p></td></tr><tr><td style="width:102.25pt;"><p style="text-align:center;"><span style="">Foreign Material</span></p></td><td style="width:155.15pt;"><p style="text-align:center;"><span style="">None</span></p></td><td style="width:168.7pt;"><p style="text-align:center;"><span style="">None</span></p></td></tr><tr><td style="width:102.25pt;"><p style="text-align:center;"><span style="">Substitution</span></p></td><td style="width:155.15pt;"><p style="text-align:center;"><span style="">></span><span style="">90%</span></p></td><td style="width:168.7pt;"><p style="text-align:center;"><span style="">></span><span style="">90%</span></p></td></tr><tr><td style="width:102.25pt;"><p style="text-align:center;"><span style="">PDI</span></p></td><td style="width:155.15pt;"><p style="text-align:center;"><span style="">&nbsp;</span></p></td><td style="width:168.7pt;"><p style="text-align:center;"><span style=""><</span><span style="">1.4</span></p></td></tr></tbody></table><p><img src="/upload/month_1610/201610121748288492.png" width="600" height="400" alt="" /><br /></p><p>&nbsp;</p><p><span style="">产品展示二:</span></p><p><span style="">Name</span><span style="">:</span><span style=""> PCL30-PEG45-FA</span></p><p><span style="">Molecular Weight</span><span style="">:</span><span style="">6000 Dalton&nbsp; </span></p><p><span style="">Cat.#</span><span style="">:</span><span style=""> R-Q-62514</span></p><p><span style="">Lot.#</span><span style="">:</span><span style=""> RP0161185</span></p><p><span style="">Stability</span><span style="">:</span><span style=""> 12 months</span></p><p><span style="">Storage</span><span style="">:</span><span style=""> -20°C in the dark</span></p><p><span style="">&nbsp;</span></p><p style="text-align:center;"><strong><span style="font-size:12.0pt;">Structure</span></strong></p><p style="text-align:center;"><span style="font-size:12.0pt;">&nbsp;</span></p><p style="text-align:center;"><img src="/upload/month_1610/201610121749094521.png" class="wordImage" width="451" height="90" alt="" /></p><p><span style="font-size:12.0pt;">&nbsp;</span></p><table border="1" cellspacing="0" cellpadding="0"> <tbody><tr><td style="width:102.25pt;"><p style="text-align:center;"><span style="">Items</span></p></td><td style="width:155.15pt;"><p style="text-align:center;"><span style="">Specification</span></p></td><td style="width:168.7pt;"><p style="text-align:center;"><span style="">Results</span></p></td></tr><tr><td style="width:102.25pt;"><p style="text-align:center;"><span style="">Appearance</span></p></td><td style="width:155.15pt;"><p style="text-align:center;"><span style="">Yellowish-brown solid</span></p></td><td style="width:168.7pt;"><p style="text-align:center;"><span style="">Yellowish-brown solid </span></p></td></tr><tr><td style="width:102.25pt;"><p style="text-align:center;"><sup><span style="">1</span></sup><span style="">H NMR</span></p></td><td style="width:155.15pt;"><p style="text-align:center;"><span style="">Identical to the structure</span></p></td><td style="width:168.7pt;"><p style="text-align:center;"><span style="">Identical to the structure</span></p></td></tr><tr><td style="width:102.25pt;"><p style="text-align:center;"><span style="">Foreign Material</span></p></td><td style="width:155.15pt;"><p style="text-align:center;"><span style="">None</span></p></td><td style="width:168.7pt;"><p style="text-align:center;"><span style="">None</span></p></td></tr><tr><td style="width:102.25pt;"><p style="text-align:center;"><span style="">Substitution</span></p></td><td style="width:155.15pt;"><p style="text-align:center;"><span style="">></span><span style="">90%</span></p></td><td style="width:168.7pt;"><p style="text-align:center;"><span style="">></span><span style="">92%</span></p></td></tr><tr><td style="width:102.25pt;"><p style="text-align:center;"><span style="">PDI</span></p></td><td style="width:155.15pt;"><p style="text-align:center;"><span style="">&nbsp;</span></p></td><td style="width:168.7pt;"><p style="text-align:center;"><span style=""><</span><span style="">1.2</span></p></td></tr></tbody></table><p>&nbsp;</p><p><img src="/upload/month_1610/201610121749201074.png" width="600" height="400" alt="" /><br /></p><p>&nbsp;</p><p style="text-align:center;"><img src="/upload/month_1610/201610121749386627.png" alt="" /><br /></p><p>&nbsp;</p><p>1<span style="">、胶束应用:抗肿瘤药物胶束、抗真菌药物胶束、抗炎药物胶束、透过血脑屏障、基因传递、放射、照影药物包封等</span></p><p>2<span style="">、制备方法:化学共聚法</span></p><p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="">物理共聚法:</span></p><p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="">溶解法:将共聚物用适量蒸馏水溶解后,加入一定量的药物,搅拌一定时间,用</span>0.45um<span style="">的滤膜过滤,得半透明乳光胶束溶液。</span></p><p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="">乳化溶剂蒸发法:共聚物溶于水,加入药物的氯仿溶液,超声或匀浆一定时间,蒸发除去氯仿,</span>0.45um<span style="">的滤膜过滤,得半透明乳光胶束溶液。</span></p><p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="">透析法:将共聚物和药物溶于与水混溶的有机溶剂如三氯甲烷、二氯甲烷、乙醇、二甲基甲酰胺或四氢呋喃中,装于透析膜中,用</span>PBS<span style="">或水透析一定时间,</span>0.45um<span style="">的滤膜过滤,得半透明乳光胶束溶液。</span></p><p>3<span style="">、胶束材料选取:</span><span style="">做胶束一般选用二嵌段共聚物,</span><span style="">疏水段的分子量大于</span><span style="">PEG</span><span style="">或相等,</span><span style="">当疏水链大于亲水链,胶束的稳定性更高,载药性越好。但一般疏水段的分子量**不大于8000,</span><span style="">大于</span>8000<span style="">容易产生沉淀,而亲水段的</span>PEG<span style="">一般在</span>5000<span style="">分子量以下,也就是重复单元在</span>117<span style="">个以内为佳。做胶束我们一般会选用硬度较小的疏水性材料,比如</span>PCL<span style="">、</span>PDLLA<span style="">和</span>PLGA<span style="">,但</span>PLGA<span style="">比</span>PDLLA<span style="">降解快。</span></p><p><span style="">材料的硬度:</span><span style="">PLLA&gt;PLGA&gt;PDLLA&gt;PCL</span></p><p><span style="">西安瑞禧生物科技有限公司推荐的几款做胶束的材料有:</span></p><p><span style="">PCL2000-PEG2000&nbsp; PCL2000-PEG1000&nbsp;&nbsp; PCL5000-PEG2000</span></p><p><span style="">PDLLA2000-PEG2000&nbsp;&nbsp; PDLLA5000-PEG2000&nbsp; PDLLA2000-PEG1000</span></p><p><span style="">PLGA2000-PEG2000&nbsp;&nbsp;&nbsp; PLGA5000-PEG2000</span></p><p>&nbsp;&nbsp;&nbsp; 4<span style="">、两种提高胶束有效性的方法:①对嵌段共聚物进行化学修饰,制成功能性的嵌段共聚物。</span></p><p><span style="">目的:提高胶束稳定性,进一步延长胶束的循环时间,可暂时控制药物的释放。</span></p><p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<span style="">②在胶束递药系统中添加助剂,如通道蛋白和金属微粒。</span></p><p><span style="">目的:控制药物的释放。例如,通过外部刺激实现脉冲释药</span></p><p>&nbsp;</p><p><strong><span style="font-size:14.0pt;">不同方法制备的聚合物胶束的释药特点</span></strong></p><p>1<span style="">、化学结合的胶束释药特点</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </p><p><span style="">化学结合法制备的载药胶束主要通过两种方式释药:聚合物胶束降解后胶束结合药物的共价键断开释药;或胶束结合药物的共价键断开,然后药物从胶束扩散释药。体外释放实验表明,许多聚合物胶束体现出缓释的特点。</span></p><p>&nbsp;</p><p>2<span style="">、物理结合的胶束释药特点</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </p><p><span style="">物理包埋法制备的胶束常常通过扩散作用释药。一般来说,物理包埋法制备的胶束比化学结合法制备的胶束释药更快,释药速度与</span>3 <span style="">个因素有关:</span></p><p>&nbsp;(1)<span style="">药物与疏水核的相容性良好的胶束核与药物相容性可明显地延缓药物的释放。将</span>PEO-b-P(Asp) <span style="">疏水核引入饱和脂肪酸,结果包载的脂肪族药物两性霉素</span>B <span style="">的溶血性降低,意味着药物的释放速度变小。</span></p><p>(2)<span style="">氢键作用力胶束核与药物之间具有强的氢键作用力也可以延缓药物释放。制备了</span>PDLLA <span style="">区含有游离羧基的</span>PEO-PDLLA <span style="">胶束,并发现随着游离羧基浓度提高,药物载药量提高而释药速率降低,可能是因为胶束核和药物的氢键作用力增强所致。</span>&nbsp;</p><p>(3)<span style="">载药量研究表明,药物的载药量也会对释药速率产生影响。阿霉素于聚丙交酯</span>/ <span style="">聚乙二醇</span>/ <span style="">聚丙交酯</span>( PLLA-b-PEO-b-PLLA) <span style="">胶束中载药量为</span>1 %<span style="">和</span>3 %<span style="">时,分别在</span>6<span style="">、</span>8 <span style="">天释放了</span>50 %<span style="">、</span>17 %<span style="">的药物。</span></p><p><strong><span style="font-size:12.0pt;">静电作用法制备的胶束</span></strong>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </p><p><span style="">静电作用法制备的胶束通过药物与生理介质中游离的离子或蛋白交换释药。强疏水的胶束核可加强核与药物的静电作用</span>,<span style="">通过使药物与介质中的离子交换受阻达到缓释。通过静电作用法制备了顺铂的</span>PEO-b-P(Asp) <span style="">载药胶束</span>,<span style="">体外释药实验表明药物在</span>20 h<span style="">后释放了</span>50 %<span style="">。增加聚合物中疏水片段</span>P(Asp) <span style="">的比例,药物释放速度进一步降低。采用更为疏水的聚氧乙烯</span>-b-<span style="">聚谷氨</span> <span style="">酸</span>(PEO-b-P(Glu) ) <span style="">作为载体</span>,<span style="">药物的释放持续了</span>150 h<span style="">。</span></p><p>&nbsp;</p><p><strong><span style="font-size:12.0pt;">利用树状聚合物单分子制备胶束</span></strong></p><p><span style="">树状聚合物是两亲性分子,表面亲水,内部疏水,作用类似于胶束,每个胶束由单分子树状聚合物构成,因而称为单分子胶束。树状聚合物具有以下优点</span>:<span style="">能在较大的范围内和多种溶剂中保持分散状态,不聚集,不受临界胶束浓度的影响。以甲氨蝶呤</span>(MTX) <span style="">为模型药物,研究了聚酰胺</span>-<span style="">胺型</span>(PAMAM) <span style="">树状大分子与</span>MTX<span style="">的复合及体外释放。该复合物在</span>pH = 7.4 <span style="">,</span>10 m mol/L Tris-HCl<span style="">中非常稳定</span>,<span style="">表现出明显的缓释效果。当溶液中的离子强度增加时</span>,<span style="">会破坏</span>PAMAM-MTX<span style="">复合物的稳定性</span>,<span style="">缓释作用部分或全部失去</span>, <span style="">说明</span>PAMAM<span style="">树状大分子与</span>MTX<span style="">之间的相互作用属于静电作用。</span></p><p>&nbsp;</p><p><strong><span style="font-size:12.0pt;">利用嵌段的溶解能力的温度依赖性制备胶束</span></strong></p><p><span style="">相当一部分嵌段共聚物在溶液中有热敏性</span>, <span style="">具有</span>LCST <span style="">相行为,超过此温度即</span> <span style="">可形成具有壳</span>-<span style="">核的胶束结构。利用</span>pHPMAmDL-b-PEG<span style="">的温度依赖性,将</span>pHPMAmDL-b-PEG<span style="">溶于等渗的醋酸铵缓冲液中,紫杉醇溶于乙醇中加入缓冲液,加热到</span>50<span style="">℃后冷却就得到了紫杉醇聚合物胶束,胶束载药量达到</span> 22%<span style="">,体外释药实验表明药物在</span>5<span style="">、</span>20h<span style="">释放了</span>30 %<span style="">、</span>70%<span style="">。</span></p>
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