Folate-PEG-NHS聚乙二醇衍生物的制备方法介绍-叶酸聚乙二醇

西安瑞禧生物科技有限公司是国内最大的PEG生产制造商，我们提供末端活性基团取代率97%+以上的产品，产品稳定 保存2年以上。

2019年瑞禧生物的基础PEG产品大幅降价，降价产品包括有NH2-PEG-Biotin，DBCO-PEG-NH2，MAL-PEG-COOH，HS-PEG-COOH，SCM-PEG-MAL，Alkyne -PEG-COOH等等不同产品。

Sc-PEG 专利分析：

NH2-PEG-COOH

NH2-PEG-MAL

NH2-PEG-N3

NH2-PEG-Alkyne

NH2-PEG-SH

NH2-PEG-Biotin

NH2-PEG-OPSS

NH2-PEG-OH

NH2-PEG-Hydrazide

NH2-PEG-Silane

NH2-peg-Acrylates

NH2-peg-Lipoicacid

NH2-peg-Acetylthio

NH2-PEG-NitrophenylCarbonates (NPC)

NH2-PEG-ValericAcids

NH2-PEG-Acrylamide

NH2-PEG-Bromide(Br)

NH2-PEG-Vinylsulfone(VS)

NH2-PEG-Methacrylate(MA)

NH2-PEG-Iodoacetate(IA)

NH2-PEG-Chloride

DBCO-PEG-NH2

TCO-PEG-NH2

Tetrazine-PEG-NH2

NH2-PEG-Folate

NH2-PEG-CHEMS

Roche公司的长效干扰素产品专利分析：

MAL-PEG-COOH

NHS-PEG-COOH

N3-PEG-COOH

Alkyne-PEG-COOH

HS-PEG-COOH

Biotin-PEG-COOH

CHO-PEG-COOH

OPSS-PEG-COOH

Silane-peg-COOH

Acrylates-peg-COOH

Lipoicacid-peg-COOH

Tosylate-peg-COOH

NPC-PEG-COOH

SAS-PEG-COOH

SC-PEG-COOH

SCM-PEG-COOH

SG-PEG-COOH

SS-PEG-COOH

SVA-PEG-COOH

Epoxides-PEG-COOH

ValericAcids-PEG-COOH

Acrylamide-PEG-COOH

Bromide-PEG-COOH

VS-PEG-COOH

Methacrylate-PEG-COOH

IA-PEG-COOH

Chloride-PEG-COOH

DBCO-PEG-COOH

TCO-PEG-COOH

Tetrazine-PEG-COOH

Folate-PEG-COOH

CHEMS-PEG-COOH

西安瑞禧生物新的修饰策略：

采用新方法制备新的修饰剂

NHS-PEG-MAL

N3-PEG-MAL

Alkyne-PEG-MAL

Biotin-PEG-MAL

CHO-PEG-MAL

OPSS-PEG-MAL

Hydrazide-PEG-MAL

Silane-peg-MAL

Acrylates-peg-MAL

Lipoicacid-peg-MAL

Tosylate-peg-MAL

Aminooxy-PEG-MAL

NPC-PEG-MAL

SAS-PEG-MAL

SC-PEG-MAL

SCM-PEG-MAL

SG-PEG-MAL

SS-PEG-MAL

SVA-PEG-MAL

Epoxides-PEG-MAL

ValericAcids-PEG-MAL

Acrylamide-PEG-MAL

Bromide-PEG-MAL

VS-PEG-MAL

Methacrylate-PEG-MAL

IA-PEG-MAL

Chloride-PEG-MAL

DBCO-PEG-MAL

TCO-PEG-MAL

Tetrazine-PEG-MAL

Folate-PEG-MAL

CHEMS-PEG-MAL

西安瑞禧生物科技有限公司的方法：

N3-PEG-NHS

Alkyne-PEG-NHS

HS-PEG-NHS

Biotin-PEG-NHS

CHO-PEG-NHS

OPSS-PEG-NHS

Hydrazide-PEG-NHS

Silane-peg-NHS

Acrylates-peg-NHS

Lipoicacid-peg-NHS

Tosylate-peg-NHS

Acetylthio-peg-NHS

NPC-PEG-NHS

Epoxides-PEG-NHS

ValericAcids-PEG-NHS

Bromide-PEG-NHS

VS-PEG-NHS

Methacrylate-PEG-NHS

IA-PEG-NHS

Chloride-PEG-NHS

DBCO-PEG-NHS

TCO-PEG-NHS

Tetrazine-PEG-NHS

Folate-PEG-NHS

CHEMS-PEG-NHS

PEG修饰剂的批量制备取得了成功：

Biotin-PEG-SH

CHO-PEG-SH

Hydrazide-PEG-SH

Silane-peg-SH

Acrylates-peg-SH

Lipoicacid-peg-SH

Tosylate-peg-SH

Aminooxy-PEG-SH

NPC-PEG-SH

SAS-PEG-SH

SC-PEG-SH

SCM-PEG-SH

SG-PEG-SH

SS-PEG-SH

SVA-PEG-SH

Epoxides-PEG-SH

ValericAcids-PEG-SH

Acrylamide-PEG-SH

Bromide-PEG-SH

Methacrylate-PEG-SH

IA-PEG-SH

Chloride-PEG-SH

DBCO-PEG-SH

TCO-PEG-SH

Tetrazine-PEG-SH

Folate-PEG-SH

CHEMS-PEG-SH