PEG制备方法7-医用可生物降解PLGA-PEG-MAL的合成

这类共聚物的应用报道近年来越来越多。由于聚醚的存在, 使共聚物具有亲水性和柔软性,在药物控制释放中可作为表面活性剂, 微球表面修饰剂, 也可用于制备载药微球, 载药毫微球等。

目前研究得较多的为聚乙二醇2聚酯及聚乙二醇2聚氨基酸共聚物。聚乙二醇2聚酯共聚物一般用聚乙二醇与环状内酯开环共聚制备以聚乙二醇2聚乳酸共聚物的制备示例如下[ 39 ] (式22) :

聚乙二醇2聚氨基酸共聚物一般用聚乙二醇胺与环状氨基酸氮酸酐开环共聚制备, 以聚乙二醇2聚苄酯谷氨酸共聚物的制备, 示例如下[ 40 ] (式23) :

产品列表：

PLGA-PEG-NH2,PLGA-PEG-Amine 

PLGA-PEG-COOH,PLGA-PEG-carboxyl

PLGA-PEG-MAL,PLGA-PEG-Maleimide

PLGA-PEG-NHS 

PLGA-PEG-N3,PLGA-PEG-azide

PLGA-PEG-Alkyne

PLGA-PEG-SH,PLGA-PEG-Thiol

PLGA-PEG-Biotin 

PLGA-PEG-CHO,PLGA-PEG-aldehyde

PLGA-PEG-OPSS

PLGA-PEG-OH/hydroxyl

PLGA-PEG-Hydrazide/ HZ

PLGA-PEG-Silane

PLGA-PEG-Acrylates (ACRL)

PLGA-PEG-Lipoic acid/LA

PLGA-PEG-Tosyl,PLGA-PEG-Tosylate

PLGA-PEG-Acetylthio

PLGA-PEG-Aminooxy

PLGA-PEG-Nitrophenyl Carbonates (NPC)

PLGA-PEG-SAS, SC, SCM, SG, SS, SVA

PLGA-PEG-Epoxides (EPOX)

PLGA-PEG-Valeric Acids (VA)

PLGA-PEG-Acrylamide

PLGA-PEG-Bromide(Br)

PLGA-PEG-Vinylsulfone(VS)

PLGA-PEG-Methacrylate (MA)

PLGA-PEG-Iodoacetate(IA)

PLGA-PEG-Chloride

PLGA-PEG-DBCO

PLGA-PEG-TCO

PLGA-PEG-TZ,PLGA-PEG-Tetrazine

PLGA-PEG-Folate ，PLGA-PEG-FA/folic acid 

PLGA-PEG-Multi-Arms (4 arm 8arm)

PLGA-PEG-Protected Amines (FMOC, tBOC)

PLGA-PEG-CHEMS

PCL-PEG-NH2,PCL-PEG-Amine 

PCL-PEG-COOH,PCL-PEG-carboxyl

PCL-PEG-MAL,PCL-PEG-Maleimide

PCL-PEG-NHS 

PCL-PEG-N3 PCL-PEG-azide

PCL-PEG-Alkyne

PCL-PEG-SH ,PCL-PEG-Thiol

PCL-PEG-Biotin 

PCL-PEG-CHO, PCL-PEG-aldehyde

PCL-PEG-OPSS

PCL-PEG-OH /hydroxyl

PCL-PEG-Hydrazide, PCL-PEG-HZ

PCL-PEG-Silane

PCL-PEG-Acrylates (ACRL)

PCL-PEG-Lipoic acid LA

PCL-PEG-Tosyl,Tosylate

PCL-PEG-Acetylthio

PCL-PEG-Aminooxy

PCL-PEG-Nitrophenyl Carbonates (NPC)

PCL-PEG-SAS, SC, SCM, SG, SS, SVA

PCL-PEG-Epoxides (EPOX)

PCL-PEG-Valeric Acids (VA)

PCL-PEG-Acrylamide

PCL-PEG-Bromide(Br)

PCL-PEG-Vinylsulfone(VS)

PCL-PEG-Methacrylate (MA)

PCL-PEG-Iodoacetate(IA)

PCL-PEG-Chloride

PCL-PEG-DBCO

PCL-PEG-TCO

PCL-PEG-TZ/Tetrazine

PCL-PEG-Folate ，FA， folic acid 

PCL-PEG-Multi-Arms (4 arm 8arm)

PCL-PEG-Protected Amines (FMOC, tBOC)

PCL-PEG-CHEMS

PLA-PEG-NH2,PLA-PEG-Amine 

PLA-PEG-COOH,PLA-PEG-carboxyl

PLA-PEG-MAL,PLA-PEG-Maleimide

PLA-PEG-NHS 

PLA-PEG-N3 PLA-PEG-azide

PLA-PEG-Alkyne

PLA-PEG-SH ,PLA -PEG-Thiol

PLA-PEG-Biotin 

PLA-PEG-CHO, PLA -PEG-aldehyde

PLA-PEG-OPSS

PLA-PEG-OH /hydroxyl

PLA-PEG-Hydrazide, PLA -PEG-HZ

PLA-PEG-Silane

PLA-PEG-Acrylates (ACRL)

PLA-PEG-Lipoic acid LA

PLA-PEG-Tosyl,Tosylate

PLA-PEG-Acetylthio

PLA-PEG-Aminooxy

PLA-PEG-Nitrophenyl Carbonates (NPC)

PLA-PEG-SAS, SC, SCM, SG, SS, SVA

PLA-PEG-Epoxides (EPOX)

PLA-PEG-Valeric Acids (VA)

PLA-PEG-Acrylamide

PLA-PEG-Bromide(Br)

PLA-PEG-Vinylsulfone(VS)

PLA-PEG-Methacrylate (MA)

PLA-PEG-Iodoacetate(IA)

PLA-PEG-Chloride

PLA-PEG-DBCO

PLA-PEG-TCO

PLA-PEG-TZ,PLA-PEG-Tetrazine

PLA-PEG-Folate，PLA-PEG-FA， folic acid 

PLA-PEG-Multi-Arms (4 arm 8arm)

PLA-PEG-Protected Amines (FMOC, tBOC)

PLA-PEG-CHEMS

PAA-PEG-NH2,PAA-PEG-Amine 

PAA-PEG-COOH,PAA-PEG-carboxyl

PAA-PEG-MAL,PAA-PEG-Maleimide

PAA-PEG-NHS 

PAA-PEG-N3 PAA-PEG-azide

PAA-PEG-Alkyne

PAA-PEG-SH ,PAA-PEG-Thiol

PAA-PEG-Biotin 

PAA-PEG-CHO, PAA-PEG-aldehyde

PAA-PEG-OPSS

PAA-PEG-OH /hydroxyl

PAA-PEG-Hydrazide, PAA-PEG-HZ

PAA-PEG-Silane

PAA-PEG-Acrylates (ACRL)

PAA-PEG-Lipoic acid LA

PAA-PEG-Tosyl,Tosylate

PAA-PEG-Acetylthio

PAA-PEG-Aminooxy

PAA-PEG-Nitrophenyl Carbonates (NPC)

PAA-PEG-SAS, SC, SCM, SG, SS, SVA

PAA-PEG-Epoxides (EPOX)

PAA-PEG-Valeric Acids (VA)

PAA-PEG-Acrylamide

PAA-PEG-Bromide(Br)

PAA-PEG-Vinylsulfone(VS)

PAA-PEG-Methacrylate (MA)

PAA-PEG-Iodoacetate(IA)

PAA-PEG-Chloride

PAA-PEG-DBCO

PAA-PEG-TCO

PAA-PEG-TZ/Tetrazine

PAA-PEG-Folate ，PAA-PEG-FA， folic acid 

PAA-PEG-Multi-Arms (4 arm 8arm)

PAA-PEG-Protected Amines (FMOC, tBOC)

PAA-PEG-CHEMS