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MELK-T1(JNJ-47117096),CAS1610586-62-3
Catalog # | Pkg Size | Price | Quantity | Shopping Cart |
---|---|---|---|---|
R-SX-1210 | 1 | ¥ 1 | 加入购物车 |
结构式
外观 | N/A |
分子量 | 362.424984455109 |
溶解度 | N/A |
CAS号 | 1610586-62-3 |
质量控制 | N/A |
储存条件 | N/A |
保存时间 | N/A |
其他信息 | 价格1,就是价格现询 |
MELK-T1 is a potent and selective inhibitor of protein kinase MELK. MELK-T1 decreases DNA-damage tolerance in proliferating cancer cells. MELK-T1 triggered a rapid and proteasome-dependent degradation of the MELK protein. Treatment of MCF-7 breast adenocarcinoma cells with MELK-T1 induced the accumulation of stalled replication forks and double-strand breaks that culminated in a replicative senescence phenotype. MELK-T1 induced a strong phosphorylation of p53, a prolonged upregulation of p21 and a downregulation of FOXM1 target genes.西安瑞禧生物提供各种抑制剂材料。
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