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Hot APIs cancer
| Item No | Product Name | Product Description | Product Description | Inquiry |
|---|---|---|---|---|
| R-SX-011 | KU-55933CAS587871-26-9 | KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.西安瑞禧生物提供各种抑制剂材料。 | 查看详细 | |
| R-SX-012 | TWS11CAS601514-19-6 | TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay; capable of inducing neuronal differentiation and may be useful to stem cell biology.西安瑞禧生物提供各种抑制剂材料。 | 查看详细 | |
| R-SX-013 | NVPBKM120CAS944396-07-0 | BKM120 (NVP-BKM120, Buparlisib) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Phase 2.西安瑞禧生物提供各种抑制剂材料。 | 查看详细 | |
| R-SX-014 | Torkinib;PP242CAS1092351-67-1 | Torkinib (PP 242) 是选择性，ATP竞争型的 mTOR 抑制剂，IC50 为 8 nM。PP242 抑制 mTORC1 和 mTORC2 的 IC50 分别为 30 nM 和 58 nM。西安瑞禧生物提供各种抑制剂材料。 | 查看详细 | |
| R-SX-015 | XL765CAS1123889-87-1 | Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.西安瑞禧生物提供各种抑制剂材料。 | 查看详细 | |
| R-SX-016 | PI103 Free baseCAS371935-79-4 | PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM.西安瑞禧生物提供各种抑制剂材料。 | 查看详细 | |
| R-SX-017 | YM201636CAS371942-69-7 | YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM, less potent to p110α and insensitive to Fabl (yeast orthologue).西安瑞禧生物提供各种抑制剂材料。 | 查看详细 | |
| R-SX-018 | Torin2CAS1223001-51-1 | Torin 2 是一种 mTOR 抑制剂，抑制细胞内 mTOR 活性，EC50 为 0.25 nM，比作用于 PI3K (EC50: 200 nM) 选择性高 800 倍。体外酶实验中，Torin 2 还抑制 DNA-PK，IC50 为 0.5 nM。Torin 2 抑制 mTORC1 和 mTORC2。 西安瑞禧生物提供各种抑制剂材料。 | 查看详细 | |
| R-SX-019 | BYL719CAS1217486-61-7 | Alpelisib (BYL719) is a potent and selective PI3Kα inhibitor with IC50 of 5 nM in a cell-free assay, and minimal effect on PI3Kβ/γ/δ. Phase 2.西安瑞禧生物提供各种抑制剂材料。 | 查看详细 | |
| R-SX-020 | GDC0941; PictilisibCAS957054-33-0 | Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.西安瑞禧生物提供各种抑制剂材料。 | 查看详细 | |
| R-SX-021 | Bikinin; AbrasinCAS188011-69-0 | Bikinin 是一种非甾体类的，植物性 GSK-3/Shaggy-like kinases 的 ATP 竞争性抑制剂，可激活 BR 信号通路,西安瑞禧生物提供各种抑制剂材料。 | 查看详细 | |
| R-SX-022 | GDC0941CAS957054-30-7 | Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM in cell-free assays, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Phase 2.西安瑞禧生物提供各种抑制剂材料。 | 查看详细 | |
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