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PEG修饰工艺的优化(NH2-PEG-MAL/COOH/NHS/FA/Biotin/SH/HZ)

时间:2019-07-03 11:37:24       浏览:102

PEG修饰工艺的优化(NH2-PEG-MAL/COOH/NHS/FA/Biotin/SH/HZ

PEG修饰反应参数的优化

Ø       建立反应动力学,包括位点反应动力学和蛋白分

    子反应动力学,优化反应时间

Ø         优化反应的pH

Ø         优化PEG与蛋白的摩尔比

Ø         优化反应体系

 

蛋白分子的修饰反应动力学

产品列表:

Tosylate-peg-FA

Acetylthio-peg-FA

Aminooxy-PEG-FA

NPC-PEG-FA

SAS-PEG-FA

SC-PEG-FA

SCM-PEG-FA

SG-PEG-FA

SS-PEG-FA

SVA-PEG-FA

Epoxides-PEG-FA

ValericAcids-PEG-FA

Acrylamide-PEG-FA

Bromide-PEG-FA

VS-PEG-FA

Methacrylate-PEG-FA

IA-PEG-FA

Chloride-PEG-FA

DBCO-PEG-FA

TCO-PEG-FA

Tetrazine-PEG-FA

CHEMS-PEG-FA

 

PEG修饰的位点反应动力学

DBCO-PEG-Tosylate

DBCO-PEG-Acetylthio

DBCO-PEG-Aminooxy

DBCO-PEG-NPC

DBCO-PEG-SAS

DBCO-PEG-SC

DBCO-PEG-SCM

DBCO-PEG-SG

DBCO-PEG-SS

DBCO-PEG-SVA

DBCO-PEG-Epoxides

DBCO-PEG-ValericAcids

DBCO-PEG-Acrylamide

DBCO-PEG-Bromide

DBCO-PEG-Vinylsulfone

DBCO-PEG-Methacrylate

DBCO-PEG-Iodoacetate

DBCO-PEG-Chloride

DBCO-PEG-Folate

DBCO-PEG-CHEMS

 

PEG醛修饰药用蛋白的优化反应

TCO-PEG-Tosylate

TCO-PEG-Acetylthio

TCO-PEG-Aminooxy

TCO-PEG-NPC

TCO-PEG-SAS

TCO-PEG-SC

TCO-PEG-SCM

TCO-PEG-SG

TCO-PEG-SS

TCO-PEG-SVA

TCO-PEG-Epoxides

TCO-PEG-ValericAcids

TCO-PEG-Acrylamide

TCO-PEG-Bromide

TCO-PEG-Vinylsulfone

TCO-PEG-Methacrylate

TCO-PEG-Iodoacetate

TCO-PEG-Chloride

TCO-PEG-Folate

TCO-PEG-CHEMS

 

分离产物分析

4 arm-PEG-NH2

4 arm-PEG-COOH

4 arm-PEG-MAL

4 arm-PEG-NHS

4 arm-PEG-N3

4 arm-PEG-Alkyne

4 arm-PEG-SH

4 arm-PEG-Biotin

4 arm-PEG-CHO

4 arm-PEG-OPSS

4 arm-PEG-Hydrazide

4 arm-peg-silane

4 arm-peg-Acrylates

4 arm-peg-Lipoicacid

4 arm-peg-Tosylate

4 arm-peg-Acetylthio

4 arm-PEG-Aminooxy

4 arm-PEG-NitrophenylCarbonates (NPC)

4 arm-PEG-SAS

4 arm-PEG-SC

4 arm-PEG-SCM

4 arm-PEG-SG

4 arm-PEG-SS

4 arm-PEG-SVA

 

膜耦合修饰工艺制备PEG化药用蛋白

8 arm-PEG-NH2

8 arm-PEG-COOH

8 arm-PEG-MAL

8 arm-PEG-NHS

8 arm-PEG-N3

8 arm-PEG-Alkyne

8 arm-PEG-SH

8 arm-PEG-Biotin

8 arm-PEG-CHO

8 arm-PEG-OPSS

8 arm-PEG-Hydrazide

8 arm-peg-silane

8 arm-peg-Acrylates

8 arm-peg-Lipoicacid

8 arm-peg-Tosylate

8 arm-peg-Acetylthio

8 arm-PEG-Aminooxy

8 arm-PEG-NitrophenylCarbonates (NPC)

 


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